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[[Image:2nou.gif|left|200px]]
{{Seed}}
[[Image:2nou.png|left|200px]]


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{{STRUCTURE_2nou|  PDB=2nou  |  SCENE=  }}  
{{STRUCTURE_2nou|  PDB=2nou  |  SCENE=  }}  


'''Membrane induced structure of Scyliorhinin I: A Dual NK1/NK2 agonist'''
===Membrane induced structure of Scyliorhinin I: A Dual NK1/NK2 agonist===




==Overview==
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Scyliorhinin I, a linear decapeptide, is the only known tachykinin that shows high affinity for both NK-1 and NK-2 binding sites and low affinity for NK-3 binding sites. As a first step to understand the structure-activity relationship, we report the membrane-induced structure of scyliorhinin I with the aid of circular dichroism and 2D-(1)H NMR spectroscopy. Sequence specific resonance assignments of protons have been made from correlation spectroscopy (TOCSY, DQF-COSY) and NOESY spectroscopy. The interproton distance constraints and dihedral angle constraints have been utilized to generate a family of structures using DYANA. The superimposition of 20 final structures has been reported with backbone pairwise root mean-square deviation of 0.38 +/- 0.19 A. The results show that scyliorhinin I exists in a random coil state in aqueous environments, whereas helical conformation is induced toward the C-terminal region of the peptide (D4-M10) in the presence of dodecyl phosphocholine micelles. Analysis of NMR data is suggestive of the presence of a 3(10)-helix that is in equilibrium with an alpha-helix in this region from residue 4 to 10. An extended highly flexible N-terminus of scyliorhinin I displays some degree of order and a possible turn structure. Observed conformational features have been compared with respect to that of substance P and neurokinin A, which are endogenous agonists of NK-1 and NK-2 receptors, respectively.
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{{ABSTRACT_PUBMED_15731392}}


==About this Structure==
==About this Structure==
2NOU is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOU OCA].  
2NOU is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOU OCA].  


==Reference==
==Reference==
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[[Category: Helix]]
[[Category: Helix]]
[[Category: Lipid induced conformation]]
[[Category: Lipid induced conformation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:43:10 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:47:42 2008''

Revision as of 08:47, 29 July 2008

File:2nou.png

Template:STRUCTURE 2nou

Membrane induced structure of Scyliorhinin I: A Dual NK1/NK2 agonist

Template:ABSTRACT PUBMED 15731392

About this Structure

2NOU is a Single protein structure. Full experimental information is available from OCA.

Reference

Membrane-Induced Structure of Scyliorhinin I: A Dual NK1/NK2 Agonist., Dike A, Cowsik SM, Biophys J. 2005 May;88(5):3592-600. Epub 2005 Feb 24. PMID:15731392

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