2npr: Difference between revisions

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[[Image:2npr.gif|left|200px]]
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[[Image:2npr.png|left|200px]]


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{{STRUCTURE_2npr|  PDB=2npr  |  SCENE=  }}  
{{STRUCTURE_2npr|  PDB=2npr  |  SCENE=  }}  


'''Structural Studies on Plasmodium vivax Merozoite Surface Protein-1'''
===Structural Studies on Plasmodium vivax Merozoite Surface Protein-1===




==Overview==
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Plasmodium vivax infection is the second most common cause of malaria throughout the world. Like other Plasmodium species, P. vivax has a large protein complex, MSP-1, located on the merozoite surface. The C-terminal MSP-1 sub-unit, MSP-1(42), is cleaved during red blood cell invasion, causing the majority of the complex to be shed and leaving only a small 15kDa sub-unit, MSP-1(19), on the merozite surface. MSP-1(19) is considered a strong vaccine candidate. We have determined the solution structure of MSP-1(19) from P. vivax using nuclear magnetic resonance (NMR) and show that, like in other Plasmodium species, it consists of two EGF-like domains that are oriented head-to-tail. The protein has a flat, disk-like shape with a highly charged surface. When MSP-1(19) is part of the larger MSP-1(42) precursor it exists as an independent domain with no stable contacts to the rest of the sub-unit. Gel filtration and analytical ultracentrifugation experiments indicate that P. vivax MSP-1(42) exists as a dimer in solution. MSP-1(19) itself is a monomer, however, 35 amino-acids immediately upstream of its N-terminus are sufficient to cause dimerization. Our data suggest that if MSP-1(42) exists as a dimer in vivo, secondary processing would cause the dissociation of two tightly linked MSP-1(19) proteins on the merozoite surface just prior to invasion.
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{{ABSTRACT_PUBMED_17343930}}


==About this Structure==
==About this Structure==
2NPR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPR OCA].  
2NPR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPR OCA].  


==Reference==
==Reference==
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[[Category: Morgan, W D.]]
[[Category: Morgan, W D.]]
[[Category: Egf-like domain]]
[[Category: Egf-like domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:45:16 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:49:17 2008''

Revision as of 16:49, 28 July 2008

File:2npr.png

Template:STRUCTURE 2npr

Structural Studies on Plasmodium vivax Merozoite Surface Protein-1

Template:ABSTRACT PUBMED 17343930

About this Structure

2NPR is a Single protein structure of sequence from Plasmodium vivax. Full experimental information is available from OCA.

Reference

Structural studies on Plasmodium vivax merozoite surface protein-1., Babon JJ, Morgan WD, Kelly G, Eccleston JF, Feeney J, Holder AA, Mol Biochem Parasitol. 2007 May;153(1):31-40. Epub 2007 Jan 30. PMID:17343930

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