2nq3: Difference between revisions

Line 1:

[[Image:2nq3.~~gif~~|left|200px]]

[[Image:2nq3.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase~~'''~~

===Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase===

~~==Overview==~~

We have cloned a new protein that interacts with the hematopoietic DNA-binding transcription factor, p45/NF-E2, by screening a human erythroleukemia cell cDNA library with the yeast two-hybrid approach. Predicted peptide sequence and chromosomal mapping identified the cloned molecule to be the product of the human ortholog of the mouse Itch gene, which has been implicated previously in the regulation of growth and differentiation of erythroid and lymphoid cells. Transfection experiments indicate that this human ITCH protein can act as a transcriptional corepressor of p45/NF-E2. Our data provide novel insights into the functional roles of the mammalian ITCH proteins in the development of hematopoietic cell lineages.

==About this Structure==

2NQ3 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ3 OCA].

2NQ3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ3 OCA].

==Reference==

~~Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2., Chen X, Wen S, Fukuda MN, Gavva NR, Hsu D, Akama TO, Yang-Feng T, Shen CK, Genomics. 2001 Apr 15;73(2)~~:~~238-41.~~ PMID:~~[http~~://~~www.ncbi.nlm.nih.gov~~/~~pubmed/11318614 11318614]~~

[[Category: Homo sapiens]]

~~[[Category: Single protein]]~~

[[Category: Arrowsmith, C H.]]

[[Category: Avvakumov, G V.]]

Line 39:

Line 36:

[[Category: Structural genomics consortium]]

[[Category: Ubl conjugation pathway]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 09~~:46:~~09 2008~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:30:25 2009''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2nq3.gif|left|200px]]
+{{Seed}}
+[[Image:2nq3.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2nq3|  PDB=2nq3  |  SCENE=  }}
-'''Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase'''
+===Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase===
-==Overview==
-We have cloned a new protein that interacts with the hematopoietic DNA-binding transcription factor, p45/NF-E2, by screening a human erythroleukemia cell cDNA library with the yeast two-hybrid approach. Predicted peptide sequence and chromosomal mapping identified the cloned molecule to be the product of the human ortholog of the mouse Itch gene, which has been implicated previously in the regulation of growth and differentiation of erythroid and lymphoid cells. Transfection experiments indicate that this human ITCH protein can act as a transcriptional corepressor of p45/NF-E2. Our data provide novel insights into the functional roles of the mammalian ITCH proteins in the development of hematopoietic cell lineages.
 ==About this Structure==
-NQ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ3 OCA].
+NQ3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ3 OCA].
 ==Reference==
-Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2., Chen X, Wen S, Fukuda MN, Gavva NR, Hsu D, Akama TO, Yang-Feng T, Shen CK, Genomics. 2001 Apr 15;73(2):238-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11318614 11318614]
+<ref group="xtra">PMID:11318614</ref><ref group="xtra">PMID:9647693</ref><ref group="xtra">PMID:11046148</ref><ref group="xtra">PMID:12226085</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
 [[Category: Arrowsmith, C H.]]
 [[Category: Avvakumov, G V.]]
@@ Line 39: / Line 36: @@
 [[Category: Structural genomics consortium]]
 [[Category: Ubl conjugation pathway]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:46:09 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:30:25 2009''