2nse: Difference between revisions

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[[Image:2nse.jpg|left|200px]]
{{Seed}}
[[Image:2nse.png|left|200px]]


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{{STRUCTURE_2nse|  PDB=2nse  |  SCENE=  }}  
{{STRUCTURE_2nse|  PDB=2nse  |  SCENE=  }}  


'''BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE SUBSTRATE COMPLEX'''
===BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE SUBSTRATE COMPLEX===




==Overview==
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Nitric oxide, a key signaling molecule, is produced by a family of enzymes collectively called nitric oxide synthases (NOS). Here, we report the crystal structure of the heme domain of endothelial NOS in tetrahydrobiopterin (H4B)-free and -bound forms at 1.95 A and 1.9 A resolution, respectively. In both structures a zinc ion is tetrahedrally coordinated to pairs of symmetry-related cysteine residues at the dimer interface. The phylogenetically conserved Cys-(X)4-Cys motif and its strategic location establish a structural role for the metal center in maintaining the integrity of the H4B-binding site. The unexpected recognition of the substrate, L-arginine, at the H4B site indicates that this site is poised to stabilize a positively charged pterin ring and suggests a model involving a cationic pterin radical in the catalytic cycle.
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{{ABSTRACT_PUBMED_9875848}}


==About this Structure==
==About this Structure==
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[[Category: Nitric oxide synthase]]
[[Category: Nitric oxide synthase]]
[[Category: Tetrahydrobiopterin]]
[[Category: Tetrahydrobiopterin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:51:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:29:38 2008''

Revision as of 16:29, 28 July 2008

File:2nse.png

Template:STRUCTURE 2nse

BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE SUBSTRATE COMPLEX

Template:ABSTRACT PUBMED 9875848

About this Structure

2NSE is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center., Raman CS, Li H, Martasek P, Kral V, Masters BS, Poulos TL, Cell. 1998 Dec 23;95(7):939-50. PMID:9875848

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