2nsn: Difference between revisions

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[[Image:2nsn.~~gif~~|left|200px]]

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~~'''~~Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1~~'''~~

===Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1===

~~==Overview==~~

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~~Nod~~-~~like receptors (NLRs), Nod1 and Nod2 are cytosolic detectors of pathogen~~-~~associated molecular patterns (PAMPs). Nod1 is a three-domain protein~~, ~~consisting of a caspase activation and recruitment domain (CARD)~~, ~~a nucleotide-binding oligomerization domain (NOD), and a leucine-rich repeat domain (LRR). The binding of PAMPs~~ to the ~~LRR results in the activation of signaling through homophilic CARD-CARD interactions~~. ~~Several CARD structures have been determined, including a recent NMR structure of Nod1 CARD~~. ~~In contrast to the reported NMR structure, the crystal structure reported here is a dimer~~, where ~~the sixth helix is swapped between two monomers. While the overall structure is very similar to the known CARD structures, this~~ is the ~~first report of a homodimeric CARD structure. The ability of the CARD to exist in monomeric and dimeric forms suggests another level of regulation in the activation of NLR proteins~~.

The line below this paragraph, {{ABSTRACT_PUBMED_17173864}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17173864 is the PubMed ID number.

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==About this Structure==

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[[Category: Ramaswamy, S.]]

[[Category: Six helix greek key motif]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 09~~:51:49 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:44:23 2008''

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-[[Image:2nsn.gif|left|200px]]
+{{Seed}}
+[[Image:2nsn.png|left|200px]]
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 {{STRUCTURE_2nsn|  PDB=2nsn  |  SCENE=  }}
-'''Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1'''
+===Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1===
-==Overview==
+<!--
-Nod-like receptors (NLRs), Nod1 and Nod2 are cytosolic detectors of pathogen-associated molecular patterns (PAMPs). Nod1 is a three-domain protein, consisting of a caspase activation and recruitment domain (CARD), a nucleotide-binding oligomerization domain (NOD), and a leucine-rich repeat domain (LRR). The binding of PAMPs to the LRR results in the activation of signaling through homophilic CARD-CARD interactions. Several CARD structures have been determined, including a recent NMR structure of Nod1 CARD. In contrast to the reported NMR structure, the crystal structure reported here is a dimer, where the sixth helix is swapped between two monomers. While the overall structure is very similar to the known CARD structures, this is the first report of a homodimeric CARD structure. The ability of the CARD to exist in monomeric and dimeric forms suggests another level of regulation in the activation of NLR proteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_17173864}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17173864 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17173864}}
 ==About this Structure==
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 [[Category: Ramaswamy, S.]]
 [[Category: Six helix greek key motif]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:51:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:44:23 2008''