2nuk: Difference between revisions

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[[Image:2nuk.gif|left|200px]]
{{Seed}}
[[Image:2nuk.png|left|200px]]


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{{STRUCTURE_2nuk|  PDB=2nuk  |  SCENE=  }}  
{{STRUCTURE_2nuk|  PDB=2nuk  |  SCENE=  }}  


'''Soluble Domain of the Rieske Iron-Sulfur Protein from Rhodobacter sphaeroides'''
===Soluble Domain of the Rieske Iron-Sulfur Protein from Rhodobacter sphaeroides===




==Overview==
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The Rieske [2Fe-2S] iron-sulfur protein of cytochrome bc(1) functions as the initial electron acceptor in the rate-limiting step of the catalytic reaction. Prior studies have established roles for a number of conserved residues that hydrogen bond to ligands of the [2Fe-2S] cluster. We have constructed site-specific variants at two of these residues, measured their thermodynamic and functional properties, and determined atomic resolution X-ray crystal structures for the native protein at 1.2 A resolution and for five variants (Ser-154--&gt;Ala, Ser-154--&gt;Thr, Ser-154--&gt;Cys, Tyr-156--&gt;Phe, and Tyr-156--&gt;Trp) to resolutions between 1.5 A and 1.1 A. These structures and complementary biophysical data provide a molecular framework for understanding the role hydrogen bonds to the cluster play in tuning thermodynamic properties, and hence the rate of this bioenergetic reaction. These studies provide a detailed structure-function dissection of the role of hydrogen bonds in tuning the redox potentials of [2Fe-2S] clusters.
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{{ABSTRACT_PUBMED_17223530}}


==About this Structure==
==About this Structure==
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[[Category: Nair, S K.]]
[[Category: Nair, S K.]]
[[Category: Iron sulfur cluster]]
[[Category: Iron sulfur cluster]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:55:47 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:42:38 2008''

Revision as of 21:42, 27 July 2008

File:2nuk.png

Template:STRUCTURE 2nuk

Soluble Domain of the Rieske Iron-Sulfur Protein from Rhodobacter sphaeroides

Template:ABSTRACT PUBMED 17223530

About this Structure

2NUK is a Single protein structure of sequence from Rhodobacter sphaeroides. Full crystallographic information is available from OCA.

Reference

Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters., Kolling DJ, Brunzelle JS, Lhee S, Crofts AR, Nair SK, Structure. 2007 Jan;15(1):29-38. PMID:17223530

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