2nvj: Difference between revisions

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[[Image:2nvj.jpg|left|200px]]
{{Seed}}
[[Image:2nvj.png|left|200px]]


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{{STRUCTURE_2nvj|  PDB=2nvj  |  SCENE=  }}  
{{STRUCTURE_2nvj|  PDB=2nvj  |  SCENE=  }}  


'''NMR structures of transmembrane segment from subunit a from the yeast proton V-ATPase'''
===NMR structures of transmembrane segment from subunit a from the yeast proton V-ATPase===




==Overview==
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A 900-MHz NMR study is reported of peptide sMTM7 that mimics the cytoplasmic proton hemi-channel domain of the seventh transmembrane segment (TM7) from subunit a of H(+)-V-ATPase from Saccharomyces cerevisiae. The peptide encompasses the amino acid residues known to actively participate in proton translocation. In addition, peptide sMTM7 contains the amino acid residues that upon mutation cause V-ATPase to become resistant against the inhibitor bafilomycin. 2D TOCSY and NOESY (1)H-(1)H NMR spectra are obtained of sMTM7 dissolved in d(6)-DMSO and are used to calculate the three-dimensional structure of the peptide. The NMR-based structures and corresponding dynamical features of peptide sMTM7 show that sMTM7 is composed of two alpha-helical regions. These regions are separated by a flexible hinge of two residues. The hinge acts as a ball-and-joint socket and both helical segments move independently with respect to one another. This movement in TM7 is suggested to cause the opening and closing of the cytoplasmic proton hemi-channel and enables proton translocation.
The line below this paragraph, {{ABSTRACT_PUBMED_17573038}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17573038}}


==About this Structure==
==About this Structure==
2NVJ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NVJ OCA].  
2NVJ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NVJ OCA].  


==Reference==
==Reference==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Pi helix]]
[[Category: Pi helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:57:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:29:05 2008''

Revision as of 00:29, 28 July 2008

File:2nvj.png

Template:STRUCTURE 2nvj

NMR structures of transmembrane segment from subunit a from the yeast proton V-ATPase

Template:ABSTRACT PUBMED 17573038

About this Structure

2NVJ is a Single protein structure. Full experimental information is available from OCA.

Reference

Segment TM7 from the cytoplasmic hemi-channel from VO-H+-V-ATPase includes a flexible region that has a potential role in proton translocation., Duarte AM, de Jong ER, Wechselberger R, van Mierlo CP, Hemminga MA, Biochim Biophys Acta. 2007 Sep;1768(9):2263-70. Epub 2007 May 21. PMID:17573038

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