1bgw: Difference between revisions
New page: left|200px<br /> <applet load="1bgw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bgw, resolution 2.7Å" /> '''TOPOISOMERASE RESIDU... |
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[[Image:1bgw.gif|left|200px]]<br /> | [[Image:1bgw.gif|left|200px]]<br /><applet load="1bgw" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1bgw" size=" | |||
caption="1bgw, resolution 2.7Å" /> | caption="1bgw, resolution 2.7Å" /> | ||
'''TOPOISOMERASE RESIDUES 410-1202,'''<br /> | '''TOPOISOMERASE RESIDUES 410-1202,'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of a large fragment of yeast type II DNA | The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws. | ||
==About this Structure== | ==About this Structure== | ||
1BGW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1BGW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb73_1.html Topoisomerases]]. Full crystallographic information is available from [http:// | 1BGW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1BGW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb73_1.html Topoisomerases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGW OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Topoisomerases]] | [[Category: Topoisomerases]] | ||
[[Category: Berger, J | [[Category: Berger, J M.]] | ||
[[Category: Gamblin, S | [[Category: Gamblin, S J.]] | ||
[[Category: Harrison, S | [[Category: Harrison, S C.]] | ||
[[Category: Wang, J | [[Category: Wang, J C.]] | ||
[[Category: dna-binding]] | [[Category: dna-binding]] | ||
[[Category: isomerase]] | [[Category: isomerase]] | ||
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[[Category: topoisomerase]] | [[Category: topoisomerase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:55:08 2008'' | ||
Revision as of 09:55, 21 February 2008
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TOPOISOMERASE RESIDUES 410-1202,
Overview
The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws.
About this Structure
1BGW is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1BGW with [Topoisomerases]. Full crystallographic information is available from OCA.
Reference
Structure and mechanism of DNA topoisomerase II., Berger JM, Gamblin SJ, Harrison SC, Wang JC, Nature. 1996 Jan 18;379(6562):225-32. PMID:8538787
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