2nzh: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:2nzh.gif|left|200px]]
{{Seed}}
[[Image:2nzh.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2nzh|  PDB=2nzh  |  SCENE=  }}  
{{STRUCTURE_2nzh|  PDB=2nzh  |  SCENE=  }}  


'''Crystal structure of a secretion chaperone CsaA from Bacillus subtilis in the space group P 4 21 2'''
===Crystal structure of a secretion chaperone CsaA from Bacillus subtilis in the space group P 4 21 2===




==Overview==
<!--  
Bacillus subtilis CsaA (BsCsaA) has been proposed to act as a protein-secretion chaperone in the Sec-dependent translocation pathway, possibly compensating for the lack of SecB in the Gram-positive eubacterium Bacillus subtilis. This paper presents the cloning, purification, crystallization and structures of BsCsaA in two space groups (P42(1)2 and P3(2)21) solved and refined to resolutions of 1.9 and 2.0 A, respectively. These structures complement the previously available crystal structure of CsaA from the Gram-negative eubacterium Thermus thermophilus (TtCsaA) and provide a direct structural basis for the interpretation of previously available biochemical data on BsCsaA. The sequence and structure of the proposed substrate-binding pocket are analyzed and discussed. A comparison with the TtCsaA structure reveals a different pattern of electrostatic potential in the vicinity of the binding site, which overlaps with a region of high sequence variability. In addition, the dimerization interface of this homodimeric protein is analyzed and discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_17372352}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17372352 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17372352}}


==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Homodimer]]
[[Category: Homodimer]]
[[Category: Oligonucleotide/oligosaccharide binding fold]]
[[Category: Oligonucleotide/oligosaccharide binding fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:07:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:48:30 2008''
Retrieved from "https://proteopedia.org/2nzh"