2o3d: Difference between revisions

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[[Image:2o3d.gif|left|200px]]
{{Seed}}
[[Image:2o3d.png|left|200px]]


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{{STRUCTURE_2o3d|  PDB=2o3d  |  SCENE=  }}  
{{STRUCTURE_2o3d|  PDB=2o3d  |  SCENE=  }}  


'''Structure of human SF2/ASF RNA recognition motif 2 (RRM2)'''
===Structure of human SF2/ASF RNA recognition motif 2 (RRM2)===




==Overview==
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The serine/arginine-rich (SR) protein splicing factor 2/alternative splicing factor (SF2/ASF) has a role in splicing, stability, export and translation of messenger RNA. Here, we present the structure of the RNA recognition motif (RRM) 2 from SF2/ASF, which has an RRM fold with a considerably extended loop 5 region, containing a two-stranded beta-sheet. The loop 5 extension places the previously identified SR protein kinase 1 docking sequence largely within the RRM fold. We show that RRM2 binds to RNA in a new way, by using a tryptophan within a conserved SWQLKD motif that resides on helix alpha1, together with amino acids from strand beta2 and a histidine on loop 5. The linker connecting RRM1 and RRM2 contains arginine residues, which provide a binding site for the mRNA export factor TAP, and when TAP binds to this region it displaces RNA bound to RRM2.
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(as it appears on PubMed at http://www.pubmed.gov), where 17668007 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17668007}}


==About this Structure==
==About this Structure==
2O3D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3D OCA].  
2O3D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3D OCA].  


==Reference==
==Reference==
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[[Category: Rna binding protein]]
[[Category: Rna binding protein]]
[[Category: Rrm domain]]
[[Category: Rrm domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:16:36 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:06:49 2008''
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