2o6g: Difference between revisions

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[[Image:2o6g.gif|left|200px]]
{{Seed}}
[[Image:2o6g.png|left|200px]]


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{{STRUCTURE_2o6g|  PDB=2o6g  |  SCENE=  }}  
{{STRUCTURE_2o6g|  PDB=2o6g  |  SCENE=  }}  


'''Crystal structure of IRF-3 bound to the interferon-b enhancer'''
===Crystal structure of IRF-3 bound to the interferon-b enhancer===




==Overview==
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Transcriptional activation of the interferon-beta (IFN-beta) gene requires assembly of an enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFkappaB. These factors bind cooperatively to the IFN-beta enhancer and recruit coactivators and chromatin-remodeling proteins to the IFN-beta promoter. We describe here a crystal structure of the DNA-binding domains of IRF-3, IRF-7, and NFkappaB, bound to one half of the enhancer, and use a previously described structure of the remaining half to assemble a complete picture of enhanceosome architecture in the vicinity of the DNA. Association of eight proteins with the enhancer creates a continuous surface for recognizing a composite DNA-binding element. Paucity of local protein-protein contacts suggests that cooperative occupancy of the enhancer comes from both binding-induced changes in DNA conformation and interactions with additional components such as CBP. Contacts with virtually every nucleotide pair account for the evolutionary invariance of the enhancer sequence.
The line below this paragraph, {{ABSTRACT_PUBMED_17574024}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17574024 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17574024}}


==About this Structure==
==About this Structure==
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[[Category: Panne, D.]]
[[Category: Panne, D.]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:23:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:03:32 2008''

Revision as of 13:03, 27 July 2008

File:2o6g.png

Template:STRUCTURE 2o6g

Crystal structure of IRF-3 bound to the interferon-b enhancer

Template:ABSTRACT PUBMED 17574024

About this Structure

2O6G is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

An atomic model of the interferon-beta enhanceosome., Panne D, Maniatis T, Harrison SC, Cell. 2007 Jun 15;129(6):1111-23. PMID:17574024

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