2o9l: Difference between revisions

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[[Image:2o9l.~~jpg~~|left|200px]]

[[Image:2o9l.png|left|200px]]

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~~'''~~AMBER refined NMR Structure of the Sigma-54 RpoN Domain Bound to the-24 Promoter Element~~'''~~

===AMBER refined NMR Structure of the Sigma-54 RpoN Domain Bound to the-24 Promoter Element===

~~==Overview==~~

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The ~~sigma subunit of bacterial RNA polymerase (RNAP) regulates gene expression by directing RNAP to specific promoters. Unlike sigma(70)-type proteins~~, the ~~alternative sigma factor, sigma(54), requires interaction with an ATPase~~ to ~~open DNA. We present~~ the ~~solution structure of the C-terminal domain of sigma~~(54) ~~bound to the -24 promoter element~~, ~~in which the conserved RpoN box motif inserts into the major groove of~~ the ~~DNA~~. ~~This structure elucidates the basis for sequence specific recognition of the~~ -~~24 element, orients sigma(54) on the promoter, and suggests how the C~~-~~terminal domain of sigma(54) interacts with RNAP.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17481658}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17481658 is the PubMed ID number.

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==About this Structure==

2O9L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O9L OCA].

2O9L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O9L OCA].

==Reference==

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[[Category: Sigma-54]]

[[Category: Transcription factor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 10~~:29:41 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:30:41 2008''

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-[[Image:2o9l.jpg|left|200px]]
+{{Seed}}
+[[Image:2o9l.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2o9l|  PDB=2o9l  |  SCENE=  }}
-'''AMBER refined NMR Structure of the Sigma-54 RpoN Domain Bound to the-24 Promoter Element'''
+===AMBER refined NMR Structure of the Sigma-54 RpoN Domain Bound to the-24 Promoter Element===
-==Overview==
+<!--
-The sigma subunit of bacterial RNA polymerase (RNAP) regulates gene expression by directing RNAP to specific promoters. Unlike sigma(70)-type proteins, the alternative sigma factor, sigma(54), requires interaction with an ATPase to open DNA. We present the solution structure of the C-terminal domain of sigma(54) bound to the -24 promoter element, in which the conserved RpoN box motif inserts into the major groove of the DNA. This structure elucidates the basis for sequence specific recognition of the -24 element, orients sigma(54) on the promoter, and suggests how the C-terminal domain of sigma(54) interacts with RNAP.
+The line below this paragraph, {{ABSTRACT_PUBMED_17481658}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17481658 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17481658}}
 ==About this Structure==
-O9L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O9L OCA].
+O9L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O9L OCA].
 ==Reference==
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 [[Category: Sigma-54]]
 [[Category: Transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:29:41 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:30:41 2008''