2ob7: Difference between revisions

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[[Image:2ob7.gif|left|200px]]
{{Seed}}
[[Image:2ob7.png|left|200px]]


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{{STRUCTURE_2ob7|  PDB=2ob7  |  SCENE=  }}  
{{STRUCTURE_2ob7|  PDB=2ob7  |  SCENE=  }}  


'''Structure of tmRNA-(SmpB)2 complex as inferred from cryo-EM'''
===Structure of tmRNA-(SmpB)2 complex as inferred from cryo-EM===




==Overview==
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A eubacterial ribosome stalled on a defective mRNA can be released through a quality control mechanism referred to as trans-translation, which depends on the coordinating binding actions of transfer-messenger RNA, small protein B, and ribosome protein S1. By means of cryo-electron microscopy, we obtained a map of the complex composed of a stalled ribosome and small protein B, which appears near the decoding center. This result suggests that, when lacking a codon, the A-site on the small subunit is a target for small protein B. To investigate the role of S1 played in trans-translation, we obtained a cryo-electron microscopic map, including a stalled ribosome, transfer-messenger RNA, and small protein Bs but in the absence of S1. In this complex, several connections between the 30 S subunit and transfer-messenger RNA that appear in the +S1 complex are no longer found. We propose the unifying concept of scaffolding for the roles of small protein B and S1 in binding of transfer-messenger RNA to the ribosome during trans-translation, and we infer a pathway of sequential binding events in the initial phase of trans-translation.
The line below this paragraph, {{ABSTRACT_PUBMED_17179154}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17179154}}


==About this Structure==
==About this Structure==
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[[Category: Smpb]]
[[Category: Smpb]]
[[Category: Tmrna]]
[[Category: Tmrna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:32:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:38:20 2008''

Revision as of 14:38, 27 July 2008

File:2ob7.png

Template:STRUCTURE 2ob7

Structure of tmRNA-(SmpB)2 complex as inferred from cryo-EM

Template:ABSTRACT PUBMED 17179154

About this Structure

Full crystallographic information is available from OCA.

Reference

Scaffolding as an organizing principle in trans-translation. The roles of small protein B and ribosomal protein S1., Gillet R, Kaur S, Li W, Hallier M, Felden B, Frank J, J Biol Chem. 2007 Mar 2;282(9):6356-63. Epub 2006 Dec 19. PMID:17179154

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