2obe: Difference between revisions

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[[Image:2obe.gif|left|200px]]
{{Seed}}
[[Image:2obe.png|left|200px]]


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{{STRUCTURE_2obe|  PDB=2obe  |  SCENE=  }}  
{{STRUCTURE_2obe|  PDB=2obe  |  SCENE=  }}  


'''Crystal Structure of Chimpanzee Adenovirus (Type 68/Simian 25) Major Coat Protein Hexon'''
===Crystal Structure of Chimpanzee Adenovirus (Type 68/Simian 25) Major Coat Protein Hexon===




==Overview==
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Virus-specific neutralizing antibodies present an obstacle to the effective use of adenovirus vectors for gene therapy and vaccination. The specific sites recognized by neutralizing antibodies have not been identified for any adenovirus, but they have been proposed to reside within the hexon, in small regions of the molecule that are exposed on the capsid surface and possess sequences that vary among serotypes. We have mapped the epitopes recognized by a panel of seven hexon-specific monoclonal antibodies that neutralize the chimpanzee adenovirus 68 (AdC68). Surface plasmon resonance experiments revealed that the antibodies compete for a single hexon binding site, and experiments with synthetic peptides indicated that this site resides within just one small surface loop. Mutations within this loop (but not in other surface loops) permitted virus to escape neutralization by all seven monoclonal antibodies and to resist neutralization by polyclonal antisera obtained from animals immunized against AdC68. These results indicate that a single small surface loop defines a major neutralization site for AdC68 hexon.
The line below this paragraph, {{ABSTRACT_PUBMED_17108028}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17108028}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structure-based identification of a major neutralizing site in an adenovirus hexon., Pichla-Gollon SL, Drinker M, Zhou X, Xue F, Rux JJ, Gao GP, Wilson JM, Ertl HC, Burnett RM, Bergelson JM, J Virol. 2007 Feb;81(4):1680-9. Epub 2006 Nov 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17108028 17108028]
Structure-based identification of a major neutralizing site in an adenovirus hexon., Pichla-Gollon SL, Drinker M, Zhou X, Xue F, Rux JJ, Gao GP, Wilson JM, Ertl HC, Burnett RM, Bergelson JM, J Virol. 2007 Feb;81(4):1680-9. Epub 2006 Nov 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17108028 17108028]
Capsid-like arrays in crystals of chimpanzee adenovirus hexon., Xue F, Burnett RM, J Struct Biol. 2006 May;154(2):217-21. Epub 2006 Jan 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16458021 16458021]
[[Category: Simian adenovirus 25]]
[[Category: Simian adenovirus 25]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Trimer]]
[[Category: Trimer]]
[[Category: Viral jellyroll]]
[[Category: Viral jellyroll]]
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