2odd: Difference between revisions

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[[Image:2odd.jpg|left|200px]]
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[[Image:2odd.png|left|200px]]


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{{STRUCTURE_2odd|  PDB=2odd  |  SCENE=  }}  
{{STRUCTURE_2odd|  PDB=2odd  |  SCENE=  }}  


'''Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor'''
===Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor===




==Overview==
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AML1/ETO results from the t(8;21) associated with 12%-15% of acute myeloid leukemia. The AML1/ETO MYND domain mediates interactions with the corepressors SMRT and N-CoR and contributes to AML1/ETO's ability to repress proliferation and differentiation of primary bone marrow cells as well as to enhance their self renewal in vitro. We solved the solution structure of the MYND domain and show it to be structurally homologous to the PHD and RING finger families of proteins. We also determined the solution structure of an MYND-SMRT peptide complex. We demonstrated that a single amino acid substitution that disrupts the interaction between the MYND domain and the SMRT peptide attenuated AML1/ETO's effects on proliferation, differentiation, and gene expression.
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{{ABSTRACT_PUBMED_17560331}}


==About this Structure==
==About this Structure==
2ODD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODD OCA].  
2ODD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODD OCA].  


==Reference==
==Reference==
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[[Category: Poly-proline]]
[[Category: Poly-proline]]
[[Category: Proline-tryptophan interaction]]
[[Category: Proline-tryptophan interaction]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:39:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:20:45 2008''

Revision as of 03:20, 28 July 2008

File:2odd.png

Template:STRUCTURE 2odd

Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor

Template:ABSTRACT PUBMED 17560331

About this Structure

2ODD is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity., Liu Y, Chen W, Gaudet J, Cheney MD, Roudaia L, Cierpicki T, Klet RC, Hartman K, Laue TM, Speck NA, Bushweller JH, Cancer Cell. 2007 Jun;11(6):483-97. PMID:17560331

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