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| {{STRUCTURE_2odl| PDB=2odl | SCENE= }} | | {{STRUCTURE_2odl| PDB=2odl | SCENE= }} |
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| '''Crystal structure of the HMW1 secretion domain from Haemophilus influenzae'''
| | ===Crystal structure of the HMW1 secretion domain from Haemophilus influenzae=== |
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| ==Overview==
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| In pathogenic Gram-negative bacteria, many virulence factors are secreted via the two-partner secretion pathway, which consists of an exoprotein called TpsA and a cognate outer membrane translocator called TpsB. The HMW1 and HMW2 adhesins are major virulence factors in nontypeable Haemophilus influenzae and are prototype two-partner secretion pathway exoproteins. A key step in the delivery of HMW1 and HMW2 to the bacterial surface involves targeting to the HMW1B and HMW2B outer membrane translocators by an N-terminal region called the secretion domain. Here we present the crystal structure at 1.92 A of the HMW1 pro-piece (HMW1-PP), a region that contains the HMW1 secretion domain and is cleaved and released during HMW1 secretion. Structural analysis of HMW1-PP revealed a right-handed beta-helix fold containing 12 complete parallel coils and one large extra-helical domain. Comparison of HMW1-PP and the Bordetella pertussis FHA secretion domain (Fha30) reveals limited amino acid homology but shared structural features, suggesting that diverse TpsA proteins have a common structural domain required for targeting to cognate TpsB proteins. Further comparison of HMW1-PP and Fha30 structures may provide insights into the keen specificity of TpsA-TpsB interactions.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17699157}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17699157 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17699157}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Hmw1]] | | [[Category: Hmw1]] |
| [[Category: Secretion domain]] | | [[Category: Secretion domain]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:40:55 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:24:41 2008'' |
