2odr: Difference between revisions

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[[Image:2odr.jpg|left|200px]]
{{Seed}}
[[Image:2odr.png|left|200px]]


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{{STRUCTURE_2odr|  PDB=2odr  |  SCENE=  }}  
{{STRUCTURE_2odr|  PDB=2odr  |  SCENE=  }}  


'''Methanococcus Maripaludis Phosphoseryl-tRNA synthetase'''
===Methanococcus Maripaludis Phosphoseryl-tRNA synthetase===




==Overview==
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A number of archaeal organisms generate Cys-tRNA(Cys) in a two-step pathway, first charging phosphoserine (Sep) onto tRNA(Cys) and subsequently converting it to Cys-tRNA(Cys). We have determined, at 3.2-A resolution, the structure of the Methanococcus maripaludis phosphoseryl-tRNA synthetase (SepRS), which catalyzes the first step of this pathway. The structure shows that SepRS is a class II, alpha(4) synthetase whose quaternary structure arrangement of subunits closely resembles that of the heterotetrameric (alphabeta)(2) phenylalanyl-tRNA synthetase (PheRS). Homology modeling of a tRNA complex indicates that, in contrast to PheRS, a single monomer in the SepRS tetramer may recognize both the acceptor terminus and anticodon of a tRNA substrate. Using a complex with tungstate as a marker for the position of the phosphate moiety of Sep, we suggest that SepRS and PheRS bind their respective amino acid substrates in dissimilar orientations by using different residues.
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{{ABSTRACT_PUBMED_17301225}}


==About this Structure==
==About this Structure==
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[[Category: Steitz, T A.]]
[[Category: Steitz, T A.]]
[[Category: Phosphoserine trna synthetase class ii]]
[[Category: Phosphoserine trna synthetase class ii]]
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