2of6: Difference between revisions

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[[Image:2of6.gif|left|200px]]
{{Seed}}
[[Image:2of6.png|left|200px]]


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{{STRUCTURE_2of6|  PDB=2of6  |  SCENE=  }}  
{{STRUCTURE_2of6|  PDB=2of6  |  SCENE=  }}  


'''Structure of immature West Nile virus'''
===Structure of immature West Nile virus===




==Overview==
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The structure of immature West Nile virus particles, propagated in the presence of ammonium chloride to block virus maturation in the low-pH environment of the trans-Golgi network, was determined by cryo-electron microscopy (cryo-EM). The structure of these particles was similar to that of immature West Nile virus particles found as a minor component of mature virus samples (naturally occurring immature particles [NOIPs]). The structures of mature infectious flaviviruses are radically different from those of the immature particles. The similarity of the ammonium chloride-treated particles and NOIPs suggests either that the NOIPs have not undergone any conformational change during maturation or that the conformational change is reversible. Comparison with the cryo-EM reconstruction of immature dengue virus established the locations of the N-linked glycosylation sites of these viruses, verifying the interpretation of the reconstructions of the immature flaviviruses.
The line below this paragraph, {{ABSTRACT_PUBMED_17376919}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17376919 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17376919}}


==About this Structure==
==About this Structure==
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[[Category: Em immature flavivirus west nile]]
[[Category: Em immature flavivirus west nile]]
[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:46:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:38:19 2008''
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