2ofm: Difference between revisions

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[[Image:2ofm.jpg|left|200px]]
{{Seed}}
[[Image:2ofm.png|left|200px]]


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{{STRUCTURE_2ofm|  PDB=2ofm  |  SCENE=  }}  
{{STRUCTURE_2ofm|  PDB=2ofm  |  SCENE=  }}  


'''1.11 A Crystal Structure of Apo Nitrophorin 4 From Rhodnius Prolixus'''
===1.11 A Crystal Structure of Apo Nitrophorin 4 From Rhodnius Prolixus===




==Overview==
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The nitrophorins from Rhodnius prolixus, the kissing bug, are heme-containing proteins used for the transport of nitric oxide to aide the insect in obtaining a blood meal. The Rhodnius nitrophorins display an eight-stranded antiparallel beta-barrel motif, typical of lipocalins, with a histidine-linked heme in the open end of the barrel. Heme is stabilized in the ferric state and highly distorted, displaying a ruffled conformation that may be of importance in the setting of the reduction potential. To help in understanding the means by which the protein matrix, an inherently soft material, is able to distort the heme from its low-energy planar conformation, we have determined the crystal structure of apo-nitrophorin 4-1.1 A resolution. Removal of the heme from nitrophorin 4 has very little effect on its structure: The heme binding cavity remains open and the loops near the cavity entrance respond to lower pH in the same manner as the intact protein. We conclude that the general stability of the lipocalin fold and apparent rigidity of the beta-barrel provide the means for distorting the heme cofactor.
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{{ABSTRACT_PUBMED_17660249}}


==About this Structure==
==About this Structure==
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[[Category: Lipocalin]]
[[Category: Lipocalin]]
[[Category: Transport protein]]
[[Category: Transport protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:48:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:46:45 2008''

Revision as of 10:46, 27 July 2008

File:2ofm.png

Template:STRUCTURE 2ofm

1.11 A Crystal Structure of Apo Nitrophorin 4 From Rhodnius Prolixus

Template:ABSTRACT PUBMED 17660249

About this Structure

2OFM is a Single protein structure of sequence from Rhodnius prolixus. Full crystallographic information is available from OCA.

Reference

Apo-nitrophorin 4 at atomic resolution., Amoia AM, Montfort WR, Protein Sci. 2007 Sep;16(9):2076-81. Epub 2007 Jul 27. PMID:17660249

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