2ogw: Difference between revisions

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[[Image:2ogw.jpg|left|200px]]
{{Seed}}
[[Image:2ogw.png|left|200px]]


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{{STRUCTURE_2ogw|  PDB=2ogw  |  SCENE=  }}  
{{STRUCTURE_2ogw|  PDB=2ogw  |  SCENE=  }}  


'''Structure of ABC type zinc transporter from E. coli'''
===Structure of ABC type zinc transporter from E. coli===




==Overview==
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ATP-binding cassette superfamily of periplasmic metal transporters are known to be vital for maintaining ion homeostasis in several pathogenic and non-pathogenic bacteria. We have determined crystal structure of the high-affinity zinc transporter ZnuA from Escherichia coli at 1.8 A resolution. This structure represents the first native (non-recombinant) protein structure of a periplasmic metal binding protein. ZnuA reveals numerous conformational features, which occur either in Zn(2+) or in Mn(2+) transporters, and presents a unique conformational state. A comprehensive comparison of ZnuA with other periplasmic ligand binding protein structures suggests vital mechanistic differences between bound and release states of metal transporters. The key new attributes in ZnuA include a C-domain disulfide bond, an extra alpha-helix proximal to the highly charged metal chelating mobile loop region, alternate conformations of secondary shell stabilizing residues at the metal binding site, and domain movements potentially controlled by salt bridges. Based on in-depth structural analyses of five metal binding transporters, we present here a mechanistic model termed as "partial domain slippage" for binding and release of Zn(2+).
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{{ABSTRACT_PUBMED_17306297}}


==About this Structure==
==About this Structure==
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[[Category: Transporter]]
[[Category: Transporter]]
[[Category: Zinc]]
[[Category: Zinc]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:53:29 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:11:27 2008''

Revision as of 01:11, 29 July 2008

File:2ogw.png

Template:STRUCTURE 2ogw

Structure of ABC type zinc transporter from E. coli

Template:ABSTRACT PUBMED 17306297

About this Structure

2OGW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural analysis of ABC-family periplasmic zinc binding protein provides new insights into mechanism of ligand uptake and release., Chandra BR, Yogavel M, Sharma A, J Mol Biol. 2007 Apr 6;367(4):970-82. Epub 2007 Jan 23. PMID:17306297

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