2ogz: Difference between revisions

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[[Image:2ogz.jpg|left|200px]]
{{Seed}}
[[Image:2ogz.png|left|200px]]


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{{STRUCTURE_2ogz|  PDB=2ogz  |  SCENE=  }}  
{{STRUCTURE_2ogz|  PDB=2ogz  |  SCENE=  }}  


'''Crystal structure of DPP-IV complexed with Lilly aryl ketone inhibitor'''
===Crystal structure of DPP-IV complexed with Lilly aryl ketone inhibitor===




==Overview==
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A series of non-covalent inhibitors of the serine protease dipeptidyl peptidase IV (DPP-IV) were found to adopt a U-shaped binding conformation in X-ray co-crystallization studies. Remarkably, Tyr547 undergoes a 70 degrees side-chain rotation to accommodate the inhibitor and allows access to a previously unexposed area of the protein backbone for hydrogen bonding.
The line below this paragraph, {{ABSTRACT_PUBMED_17239592}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17239592 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17239592}}


==About this Structure==
==About this Structure==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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