2oi4: Difference between revisions

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[[Image:2oi4.gif|left|200px]]
{{Seed}}
[[Image:2oi4.png|left|200px]]


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{{STRUCTURE_2oi4|  PDB=2oi4  |  SCENE=  }}  
{{STRUCTURE_2oi4|  PDB=2oi4  |  SCENE=  }}  


'''Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole'''
===Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole===




==Overview==
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A general route to ruthenium pyridocarbazole half-sandwich complexes is presented and applied to the synthesis of sixteen new compounds, many of which have modulated protein kinase inhibition properties. For example, the incorporation of a fluorine into the pyridine moiety increases the binding affinity for glycogen synthase kinase 3 by almost one order of magnitude. These data are supplemented with cyclic voltammetry experiments and a protein co-crystallographic study.
The line below this paragraph, {{ABSTRACT_PUBMED_17406720}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17406720 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17406720}}


==About this Structure==
==About this Structure==
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[[Category: Atp-binding,phosphorylation]]
[[Category: Atp-binding,phosphorylation]]
[[Category: Transferase,pim1,kinase]]
[[Category: Transferase,pim1,kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:58:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:18:20 2008''
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