2ojq: Difference between revisions

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[[Image:2ojq.~~gif~~|left|200px]]

[[Image:2ojq.png|left|200px]]

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~~'''~~Crystal structure of Alix V domain~~'''~~

===Crystal structure of Alix V domain===

~~==Overview==~~

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~~The modular protein Alix is a central node in endosomal~~-~~lysosomal trafficking and the budding of human immunodeficiency virus (HIV)~~-~~1. The Gag p6 protein of HIV-1 contains a LYPx(n)LxxL motif that is required for Alix-mediated budding and binds a region of Alix spanning residues 360-702.~~ The ~~structure of~~ this ~~fragment of Alix has the shape of the letter 'V' and is termed the V domain. The V domain has a topologically complex arrangement of 11 alpha-helices~~, ~~with connecting loops that cross three times between~~ the ~~two arms of~~ the ~~V. The conserved residue Phe676 is~~ at ~~the center of a large hydrophobic pocket and is crucial for binding to a peptide model of HIV-1 p6~~. ~~Overexpression of the V domain inhibits HIV-1 release from cells~~. ~~This inhibition of release~~ is ~~reversed by mutations that block binding of~~ the ~~Alix V domain to p6~~.

The line below this paragraph, {{ABSTRACT_PUBMED_17277784}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17277784 is the PubMed ID number.

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==About this Structure==

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[[Category: Lee, S.]]

[[Category: Helical]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 11~~:03:27 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:37:34 2008''

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-[[Image:2ojq.gif|left|200px]]
+{{Seed}}
+[[Image:2ojq.png|left|200px]]
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 {{STRUCTURE_2ojq|  PDB=2ojq  |  SCENE=  }}
-'''Crystal structure of Alix V domain'''
+===Crystal structure of Alix V domain===
-==Overview==
+<!--
-The modular protein Alix is a central node in endosomal-lysosomal trafficking and the budding of human immunodeficiency virus (HIV)-1. The Gag p6 protein of HIV-1 contains a LYPx(n)LxxL motif that is required for Alix-mediated budding and binds a region of Alix spanning residues 360-702. The structure of this fragment of Alix has the shape of the letter 'V' and is termed the V domain. The V domain has a topologically complex arrangement of 11 alpha-helices, with connecting loops that cross three times between the two arms of the V. The conserved residue Phe676 is at the center of a large hydrophobic pocket and is crucial for binding to a peptide model of HIV-1 p6. Overexpression of the V domain inhibits HIV-1 release from cells. This inhibition of release is reversed by mutations that block binding of the Alix V domain to p6.
+The line below this paragraph, {{ABSTRACT_PUBMED_17277784}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17277784 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17277784}}
 ==About this Structure==
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 [[Category: Lee, S.]]
 [[Category: Helical]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:03:27 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:37:34 2008''