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| {{STRUCTURE_2oki| PDB=2oki | SCENE= }} | | {{STRUCTURE_2oki| PDB=2oki | SCENE= }} |
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| '''Crystal structure of dimeric form of PfFabZ in crystal form2'''
| | ===Crystal structure of dimeric form of PfFabZ in crystal form2=== |
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| ==Overview==
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| The crystals obtained from various batches of crystallization trials of FabZ from Plasmodium falciparum exhibited non-isomorphism. The c axis of the I222 cell showed a large variation of about 16 A, from c = 81 A to c = 97 A. Complete data sets were collected for three crystal forms with varying lengths of the c axis (form 1, c = 97 A; form 2, c = 92 A; form 3, c = 81 A). The crystal structure of form 1 has been reported previously. Here, the crystal structures of the other two crystal forms are reported and a detailed structural comparison is made of the three crystal forms in order to explore the possible reasons for the existence of non-isomorphism. The conformations of three loops vary between the three crystal forms. The disposition of the loops affects the crystal packing and hence the unit-cell parameter. The crystallization condition and crystallization method employed, which change the evaporation rate, determine the crystal form of the enzyme. The present analysis shows that pH-induced intrinsic conformational changes in the protein play a key role in the observed differences. | | The line below this paragraph, {{ABSTRACT_PUBMED_17372349}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17372349 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17372349}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Non-isomorphism]] | | [[Category: Non-isomorphism]] |
| [[Category: Plasmodium]] | | [[Category: Plasmodium]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:05:54 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:26:47 2008'' |
