2oo4: Difference between revisions

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[[Image:2oo4.gif|left|200px]]
{{Seed}}
[[Image:2oo4.png|left|200px]]


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{{STRUCTURE_2oo4|  PDB=2oo4  |  SCENE=  }}  
{{STRUCTURE_2oo4|  PDB=2oo4  |  SCENE=  }}  


'''Structure of LNR-HD (Negative Regulatory Region) from human Notch 2'''
===Structure of LNR-HD (Negative Regulatory Region) from human Notch 2===




==Overview==
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Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand binding induces metalloprotease cleavage of Notch within an extracellular negative regulatory region (NRR). We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation. Extensive interdomain interactions within the NRR bury the metalloprotease site, showing that a substantial conformational movement is necessary to expose this site during activation by ligand. Leukemia-associated mutations in NOTCH1 probably release autoinhibition by destabilizing the conserved hydrophobic core of the NRR.
The line below this paragraph, {{ABSTRACT_PUBMED_17401372}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17401372 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17401372}}


==Disease==
==Disease==
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[[Category: Lnr]]
[[Category: Lnr]]
[[Category: Sea domain]]
[[Category: Sea domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:18:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:57:13 2008''
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