2ooy: Difference between revisions

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[[Image:2ooy.~~gif~~|left|200px]]

[[Image:2ooy.png|left|200px]]

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~~'''~~Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with ATP~~'''~~

===Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with ATP===

~~==Overview==~~

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The ~~5'-AMP (adenosine monophosphate)-activated protein kinase (AMPK) coordinates metabolic function with energy availability by responding~~ to ~~changes in intracellular ATP~~ (~~adenosine triphosphate) and AMP concentrations. Here, we report crystal structures~~ at 2.~~9 and 2~~.~~6 A resolution for ATP- and AMP-bound forms of a core alphabetagamma adenylate-binding domain from~~ the ~~fission yeast AMPK homolog~~. ~~ATP and AMP bind competitively to a single site in the gamma subunit, with their respective phosphate groups positioned near function~~-~~impairing mutants. Unexpectedly, ATP binds without counterions, amplifying its electrostatic effects on a critical regulatory region where all three subunits converge.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17289942}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17289942 is the PubMed ID number.

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==About this Structure==

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[[Category: Crystal structure]]

[[Category: Kinase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4~~ 11:21:26 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:40:41 2008''

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-[[Image:2ooy.gif|left|200px]]
+{{Seed}}
+[[Image:2ooy.png|left|200px]]
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 {{STRUCTURE_2ooy|  PDB=2ooy  |  SCENE=  }}
-'''Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with ATP'''
+===Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with ATP===
-==Overview==
+<!--
-The 5'-AMP (adenosine monophosphate)-activated protein kinase (AMPK) coordinates metabolic function with energy availability by responding to changes in intracellular ATP (adenosine triphosphate) and AMP concentrations. Here, we report crystal structures at 2.9 and 2.6 A resolution for ATP- and AMP-bound forms of a core alphabetagamma adenylate-binding domain from the fission yeast AMPK homolog. ATP and AMP bind competitively to a single site in the gamma subunit, with their respective phosphate groups positioned near function-impairing mutants. Unexpectedly, ATP binds without counterions, amplifying its electrostatic effects on a critical regulatory region where all three subunits converge.
+The line below this paragraph, {{ABSTRACT_PUBMED_17289942}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17289942 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17289942}}
 ==About this Structure==
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 [[Category: Crystal structure]]
 [[Category: Kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:21:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:40:41 2008''