2oqv: Difference between revisions

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[[Image:2oqv.gif|left|200px]]
{{Seed}}
[[Image:2oqv.png|left|200px]]


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{{STRUCTURE_2oqv|  PDB=2oqv  |  SCENE=  }}  
{{STRUCTURE_2oqv|  PDB=2oqv  |  SCENE=  }}  


'''Human Dipeptidyl Peptidase IV (DPP4) with piperidine-constrained phenethylamine'''
===Human Dipeptidyl Peptidase IV (DPP4) with piperidine-constrained phenethylamine===




==Overview==
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Dipeptidyl peptidase IV (DPP4) inhibitors are emerging as a new class of therapeutic agents for the treatment of type 2 diabetes. They exert their beneficial effects by increasing the levels of active glucagon-like peptide-1 and glucose-dependent insulinotropic peptide, which are two important incretins for glucose homeostasis. Starting from a high-throughput screening hit, we were able to identify a series of piperidinone- and piperidine-constrained phenethylamines as novel DPP4 inhibitors. Optimized compounds are potent, selective, and have good pharmacokinetic profiles.
The line below this paragraph, {{ABSTRACT_PUBMED_17367123}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17367123 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17367123}}


==About this Structure==
==About this Structure==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Serine-peptidase]]
[[Category: Serine-peptidase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:29:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:09:09 2008''
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