2osc: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:2osc.gif|left|200px]]
{{Seed}}
[[Image:2osc.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2osc|  PDB=2osc  |  SCENE=  }}  
{{STRUCTURE_2osc|  PDB=2osc  |  SCENE=  }}  


'''Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors'''
===Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors===




==Overview==
<!--  
A novel class of selective Tie-2 inhibitors was derived from a multi-kinase inhibitor 1. By reversing the amide connectivity and incorporating aminotriazine or aminopyridine hinge-binding moieties, excellent Tie-2 potency and KDR selectivity could be achieved with 3-substituted terminal aryl rings. X-ray co-crystal structure analysis aided inhibitor design. This series was evaluated on the basis of potency, selectivity, and rat pharmacokinetic parameters.
The line below this paragraph, {{ABSTRACT_PUBMED_17350837}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17350837 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17350837}}


==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Kim, J.]]
[[Category: Kim, J.]]
[[Category: Kinase domain tie-2]]
[[Category: Kinase domain tie-2]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:34:00 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:54:07 2008''
Retrieved from "https://proteopedia.org/2osc"