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| [[Image:2ovc.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2ovc| PDB=2ovc | SCENE= }} | | {{STRUCTURE_2ovc| PDB=2ovc | SCENE= }} |
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| '''Crystal structure of a coiled-coil tetramerization domain from Kv7.4 channels'''
| | ===Crystal structure of a coiled-coil tetramerization domain from Kv7.4 channels=== |
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| ==Overview==
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| Kv7.x (KCNQ) voltage-gated potassium channels form the cardiac and auditory I(Ks) current and the neuronal M-current. The five Kv7 subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain Tail. Here, we present the high-resolution structure of the Kv7.4 A-domain Tail together with biochemical experiments that show that the domain is a self-assembling, parallel, four-stranded coiled coil. Structural analysis and biochemical studies indicate conservation of the coiled coil in all Kv7 subtypes and that a limited set of interactions encode assembly specificity determinants. Kv7 mutations have prominent roles in arrhythmias, deafness, and epilepsy. The structure together with biochemical data indicate that A-domain Tail arrhythmia mutations cluster on the solvent-accessible surface of the subunit interface at a likely site of action for modulatory proteins. Together, the data provide a framework for understanding Kv7 assembly specificity and the molecular basis of a distinct set of Kv7 channelopathies.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17329207}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17329207 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17329207}} |
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| ==Disease== | | ==Disease== |
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| [[Category: Tetramer]] | | [[Category: Tetramer]] |
| [[Category: Voltage-gated channel]] | | [[Category: Voltage-gated channel]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:44:15 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:17:18 2008'' |
