2ow8: Difference between revisions

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[[Image:2ow8.gif|left|200px]]
{{Seed}}
[[Image:2ow8.png|left|200px]]


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{{STRUCTURE_2ow8|  PDB=2ow8  |  SCENE=  }}  
{{STRUCTURE_2ow8|  PDB=2ow8  |  SCENE=  }}  


'''Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements. This file, 2OW8, contains the 30S ribosome subunit, two tRNA, and mRNA molecules. 50S ribosome subunit is in the file 1VSA.'''
===Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements. This file, 2OW8, contains the 30S ribosome subunit, two tRNA, and mRNA molecules. 50S ribosome subunit is in the file 1VSA.===




==Overview==
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Our understanding of the mechanism of protein synthesis has undergone rapid progress in recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome functional complexes and high-resolution structures of ribosomal subunits and vacant ribosomes. Here, we present the crystal structure of the Thermus thermophilus 70S ribosome containing a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of the interactions between the ribosome, tRNA, and mRNA in the P and E sites and the ways in which tRNA structure is distorted by its interactions with the ribosome are seen. Differences between the conformations of vacant and tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure in response to tRNA binding, including significant changes in the peptidyl-transferase catalytic site.
The line below this paragraph, {{ABSTRACT_PUBMED_16962654}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16962654 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16962654}}


==About this Structure==
==About this Structure==
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[[Category: Ribosome]]
[[Category: Ribosome]]
[[Category: Trna]]
[[Category: Trna]]
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