2p22: Difference between revisions

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[[Image:2p22.jpg|left|200px]]
{{Seed}}
[[Image:2p22.png|left|200px]]


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{{STRUCTURE_2p22|  PDB=2p22  |  SCENE=  }}  
{{STRUCTURE_2p22|  PDB=2p22  |  SCENE=  }}  


'''Structure of the Yeast ESCRT-I Heterotetramer Core'''
===Structure of the Yeast ESCRT-I Heterotetramer Core===




==Overview==
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The endosomal sorting complex required for transport-I (ESCRT-I) complex, which is conserved from yeast to humans, directs the lysosomal degradation of ubiquitinated transmembrane proteins and the budding of the HIV virus. Yeast ESCRT-I contains four subunits, Vps23, Vps28, Vps37, and Mvb12. The crystal structure of the heterotetrameric ESCRT-I complex reveals a highly asymmetric complex of 1:1:1:1 subunit stoichiometry. The core complex is nearly 18 nm long and consists of a headpiece attached to a 13 nm stalk. The stalk is important for cargo sorting by ESCRT-I and is proposed to serve as a spacer regulating the correct disposition of cargo and other ESCRT components. Hydrodynamic constraints and crystallographic structures were used to generate a model of intact ESCRT-I in solution. The results show how ESCRT-I uses a combination of a rigid stalk and flexible tethers to interact with lipids, cargo, and other ESCRT complexes over a span of approximately 25 nm.
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{{ABSTRACT_PUBMED_17442384}}


==About this Structure==
==About this Structure==
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[[Category: Vps28]]
[[Category: Vps28]]
[[Category: Vps37]]
[[Category: Vps37]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:10:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:58:45 2008''

Revision as of 10:58, 27 July 2008

File:2p22.png

Template:STRUCTURE 2p22

Structure of the Yeast ESCRT-I Heterotetramer Core

Template:ABSTRACT PUBMED 17442384

About this Structure

2P22 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer., Kostelansky MS, Schluter C, Tam YY, Lee S, Ghirlando R, Beach B, Conibear E, Hurley JH, Cell. 2007 May 4;129(3):485-98. Epub 2007 Apr 19. PMID:17442384

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