2p8s: Difference between revisions

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-[[Image:2p8s.gif|left|200px]]
+{{Seed}}
+[[Image:2p8s.png|left|200px]]
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 {{STRUCTURE_2p8s|  PDB=2p8s  |  SCENE=  }}
-'''Human dipeptidyl peptidase IV/CD26 in complex with a cyclohexalamine inhibitor'''
+===Human dipeptidyl peptidase IV/CD26 in complex with a cyclohexalamine inhibitor===
-==Overview==
+<!--
-Molecular modeling was used to design a rigid analog of sitagliptin 1. The X-ray crystal structure of sitagliptin bound to DPP-4 suggested that the central beta-amino butyl amide moiety could be replaced with a cyclohexylamine group. This was confirmed by structural analysis and the resulting analog 2a was synthesized and found to be a potent DPP-4 inhibitor (IC(50)=21 nM) with excellent in vivo activity and pharmacokinetic profile.
+The line below this paragraph, {{ABSTRACT_PUBMED_17433672}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17433672 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17433672}}
 ==About this Structure==
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 [[Category: Dimer]]
 [[Category: Structure-based design]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:37:21 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:23:08 2008''

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