2phb: Difference between revisions

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-[[Image:2phb.jpg|left|200px]]
+{{Seed}}
+[[Image:2phb.png|left|200px]]
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 {{STRUCTURE_2phb|  PDB=2phb  |  SCENE=  }}
-'''An Orally Efficacious Factor Xa Inhibitor'''
+===An Orally Efficacious Factor Xa Inhibitor===
-==Overview==
+<!--
-Herein, we report the discovery of novel, proline-based factor Xa inhibitors containing a neutral P1 chlorophenyl pharmacophore. Through the additional incorporation of 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one 22, as a P4 pharmacophore, we discovered compound 7 (PD 0348292). This compound is a selective, orally bioavailable, efficacious FXa inhibitor that is currently in phase II clinical trials for the treatment and prevention of thrombotic disorders.
+The line below this paragraph, {{ABSTRACT_PUBMED_17683371}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17683371 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17683371}}
 ==Disease==
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 [[Category: Blood clotting]]
 [[Category: Fxa coagulation factor inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:06:39 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:30 2008''

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