2pjh: Difference between revisions

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[[Image:2pjh.jpg|left|200px]]
{{Seed}}
[[Image:2pjh.png|left|200px]]


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{{STRUCTURE_2pjh|  PDB=2pjh  |  SCENE=  }}  
{{STRUCTURE_2pjh|  PDB=2pjh  |  SCENE=  }}  


'''Strctural Model of the p97 N domain- npl4 UBD complex'''
===Strctural Model of the p97 N domain- npl4 UBD complex===




==Overview==
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The AAA ATPase, p97, achieves its versatility through binding to a wide range of cofactor proteins that adapt it to different cellular functions. The heterodimer UN (comprising Ufd1 and Npl4) is an adaptor complex that recruits p97 for numerous tasks, many of which involve the ubiquitin pathway. Insights into the structural specificity of p97 for its UN adaptor are currently negligible. Here, we present the solution structure of the Npl4 "ubiquitin-like" domain (UBD), which adopts a beta-grasp fold with a 3(10) helical insert. Moreover we performed a chemical shift perturbation analysis of its binding surface with the p97 N domain. We assigned the backbone amides of the p97 N domain and probed both its reciprocal binding surface with Npl4 UBD and its interaction with the p97-binding region of Ufd1. NMR data recorded on a 400-kDa full-length UN-hexamer p97 complex reveals an identical mode of interaction. We calculated a structural model for the p97 N-Npl4 UBD complex, and a comparison with the p97-p47 adaptor complex reveals subtle differences in p97 adaptor recognition and specificity.
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{{ABSTRACT_PUBMED_17491009}}


==About this Structure==
==About this Structure==
2PJH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJH OCA].  
2PJH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJH OCA].  


==Reference==
==Reference==
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[[Category: Transport protein]]
[[Category: Transport protein]]
[[Category: Ufd1]]
[[Category: Ufd1]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:14:11 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:35:10 2008''

Revision as of 13:35, 29 July 2008

File:2pjh.png

Template:STRUCTURE 2pjh

Strctural Model of the p97 N domain- npl4 UBD complex

Template:ABSTRACT PUBMED 17491009

About this Structure

2PJH is a Protein complex structure of sequences from Mus musculus. Full experimental information is available from OCA.

Reference

Detailed structural insights into the p97-Npl4-Ufd1 interface., Isaacson RL, Pye VE, Simpson P, Meyer HH, Zhang X, Freemont PS, Matthews S, J Biol Chem. 2007 Jul 20;282(29):21361-9. Epub 2007 May 9. PMID:17491009

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