2pkg: Difference between revisions

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[[Image:2pkg.~~gif~~|left|200px]]

[[Image:2pkg.png|left|200px]]

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~~'''~~Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40~~'''~~

===Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40===

~~==Overview==~~

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The ~~small t antigen (ST) of DNA tumor virus SV40 facilitates cellular transformation by disrupting~~ the ~~functions of protein phosphatase 2A (PP2A) through a poorly defined mechanism. The crystal structure of the core domain of SV40 ST bound~~ to the scaffolding subunit of human PP2A reveals that the ST core domain has a novel zinc-binding fold and interacts with the conserved ridge of HEAT repeats 3-6, which overlaps with the binding site for the B' (~~also called PR61 or B56) regulatory subunit~~. ~~ST has a lower binding affinity than B' for the PP2A core enzyme~~. ~~Consequently~~, ~~ST does not efficiently displace B' from PP2A holoenzymes in vitro~~. ~~Notably, ST inhibits PP2A phosphatase activity through its N~~-terminal J domain. These findings suggest that ST may function mainly by inhibiting the phosphatase activity of the PP2A core enzyme, and to a lesser extent by modulating assembly of the PP2A holoenzymes.

The line below this paragraph, {{ABSTRACT_PUBMED_17529992}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17529992 is the PubMed ID number.

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==About this Structure==

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[[Category: Small t antigen]]

[[Category: Sv40]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 13~~:17:50 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:10:16 2008''

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-[[Image:2pkg.gif|left|200px]]
+{{Seed}}
+[[Image:2pkg.png|left|200px]]
 <!--
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 {{STRUCTURE_2pkg|  PDB=2pkg  |  SCENE=  }}
-'''Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40'''
+===Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40===
-==Overview==
+<!--
-The small t antigen (ST) of DNA tumor virus SV40 facilitates cellular transformation by disrupting the functions of protein phosphatase 2A (PP2A) through a poorly defined mechanism. The crystal structure of the core domain of SV40 ST bound to the scaffolding subunit of human PP2A reveals that the ST core domain has a novel zinc-binding fold and interacts with the conserved ridge of HEAT repeats 3-6, which overlaps with the binding site for the B' (also called PR61 or B56) regulatory subunit. ST has a lower binding affinity than B' for the PP2A core enzyme. Consequently, ST does not efficiently displace B' from PP2A holoenzymes in vitro. Notably, ST inhibits PP2A phosphatase activity through its N-terminal J domain. These findings suggest that ST may function mainly by inhibiting the phosphatase activity of the PP2A core enzyme, and to a lesser extent by modulating assembly of the PP2A holoenzymes.
+The line below this paragraph, {{ABSTRACT_PUBMED_17529992}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17529992 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17529992}}
 ==About this Structure==
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 [[Category: Small t antigen]]
 [[Category: Sv40]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:17:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:10:16 2008''