2pmw: Difference between revisions

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[[Image:2pmw.jpg|left|200px]]
{{Seed}}
[[Image:2pmw.png|left|200px]]


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{{STRUCTURE_2pmw|  PDB=2pmw  |  SCENE=  }}  
{{STRUCTURE_2pmw|  PDB=2pmw  |  SCENE=  }}  


'''The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9)'''
===The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9)===




==Overview==
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Proprotein convertase subtilisin kexin type 9 (PCSK9) has been shown to be involved in the regulation of extracellular levels of the low-density lipoprotien receptor (LDLR). Although PCSK9 is a subtilase, it has not been shown to degrade the LDLR, and its LDLR-lowering mechanism remains uncertain. Here we report the crystal structure of human PCSK9 at 2.3 A resolution. PCSK9 has subtilisin-like pro- and catalytic domains, and the stable interaction between these domains prevents access to PCSK9's catalytic site. The C-terminal domain of PCSK9 has a novel protein fold and may mediate protein-protein interactions. The structure of PCSK9 provides insight into its biochemical characteristics and biological function.
The line below this paragraph, {{ABSTRACT_PUBMED_17502100}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17502100 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17502100}}


==About this Structure==
==About this Structure==
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[[Category: Protease]]
[[Category: Protease]]
[[Category: Subtilisin]]
[[Category: Subtilisin]]
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