2pon: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:2pon.jpg|left|200px]]
{{Seed}}
[[Image:2pon.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2pon|  PDB=2pon  |  SCENE=  }}  
{{STRUCTURE_2pon|  PDB=2pon  |  SCENE=  }}  


'''Solution structure of the Bcl-xL/Beclin-1 complex'''
===Solution structure of the Bcl-xL/Beclin-1 complex===




==Overview==
<!--  
Beclin-1, originally identified as a Bcl-2 binding protein, is an evolutionarily conserved protein required for autophagy. The direct interaction between Beclin-1 and Bcl-2 or Bcl-xL provides a potential convergence point for apoptosis and autophagy, two programmed cell death processes. Given the functional significance of the interaction between Beclin-1 and Bcl-2/Bcl-xL, we performed detailed biochemical and structural characterizations of this interaction. We demonstrated that the Bcl-xL-binding domain of Beclin-1 contains a BH3 domain. Therefore, Beclin-1 is a new member of the BH3-only family proteins. The structure of Bcl-xL in complex with the Beclin-1 BH3 domain was determined at high resolution by NMR spectroscopy. Although similar to other known BH3 domains, the Beclin-1 BH3 domain displays its own distinct features in the complex with Bcl-xL. Systematic analysis of all known Bcl-xL/BH3 domain complexes helped us to identify the molecular basis underlying the capacity of Bcl-xL to recognize diverse target sequences.
The line below this paragraph, {{ABSTRACT_PUBMED_17659302}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17659302 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17659302}}


==About this Structure==
==About this Structure==
2PON is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PON OCA].  
2PON is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PON OCA].  


==Reference==
==Reference==
Line 31: Line 35:
[[Category: Bcl-2 family protein]]
[[Category: Bcl-2 family protein]]
[[Category: Beclin-1]]
[[Category: Beclin-1]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:32:58 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:38:50 2008''

Revision as of 20:38, 27 July 2008

File:2pon.png

Template:STRUCTURE 2pon

Solution structure of the Bcl-xL/Beclin-1 complex

Template:ABSTRACT PUBMED 17659302

About this Structure

2PON is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1., Feng W, Huang S, Wu H, Zhang M, J Mol Biol. 2007 Sep 7;372(1):223-35. Epub 2007 Jun 30. PMID:17659302

Page seeded by OCA on Sun Jul 27 23:38:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2pon&oldid=671636"