2pov: Difference between revisions

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[[Image:2pov.gif|left|200px]]
{{Seed}}
[[Image:2pov.png|left|200px]]


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{{STRUCTURE_2pov|  PDB=2pov  |  SCENE=  }}  
{{STRUCTURE_2pov|  PDB=2pov  |  SCENE=  }}  


'''The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide'''
===The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide===




==Overview==
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Three benzene-1,3-disulfonamide derivatives were investigated for their interaction with 12 mammalian alpha-carbonic anhydrases (CAs, EC 4.2.1.1), and three bacterial/archaeal CAs belonging to the alpha-, beta-, and gamma-CA class, respectively. X-ray crystal structure of the three inhibitors in complex with the dominant human isozyme CA II revealed a particular binding mode within the cavity. The sulfonamide group in meta-position to the Zn(2+)-coordinated SO(2)NH(2) moiety was oriented toward the hydrophilic side of the active site cleft, establishing hydrogen bonds with His64, Asn67, Gln92, and Thr200. The plane of the phenyl moiety of the inhibitors was rotated by 45 degrees and tilted by 10 degrees with respect to its most recurrent orientation in other CA II-sulfonamide complexes.
The line below this paragraph, {{ABSTRACT_PUBMED_17540563}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17540563 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17540563}}


==About this Structure==
==About this Structure==
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[[Category: Carbonic anhydrase ii]]
[[Category: Carbonic anhydrase ii]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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