2pr3: Difference between revisions

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-[[Image:2pr3.jpg|left|200px]]
+{{Seed}}
+[[Image:2pr3.png|left|200px]]
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 {{STRUCTURE_2pr3|  PDB=2pr3  |  SCENE=  }}
-'''Factor XA inhibitor'''
+===Factor XA inhibitor===
-==Overview==
+<!--
-A novel series of pyrrolidine-1,2-dicarboxamides was discovered as factor Xa inhibitors using structure-based drug design. This series consisted of a neutral 4-chlorophenylurea P1, a biphenylsulfonamide P4 and a D-proline scaffold (1, IC(50) = 18 nM). Optimization of the initial hit resulted in an orally bioavailable, subnanomolar inhibitor of factor Xa (13, IC(50) = 0.38 nM), which was shown to be efficacious in a canine electrolytic model of thrombosis with minimal bleeding.
+The line below this paragraph, {{ABSTRACT_PUBMED_17581239}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17581239 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17581239}}
 ==Disease==
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 [[Category: Blood clotting]]
 [[Category: Fxa coagulation factor inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:39:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:12:58 2008''

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