2psm: Difference between revisions

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[[Image:2psm.jpg|left|200px]]
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[[Image:2psm.png|left|200px]]


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{{STRUCTURE_2psm|  PDB=2psm  |  SCENE=  }}  
{{STRUCTURE_2psm|  PDB=2psm  |  SCENE=  }}  


'''Crystal structure of Interleukin 15 in complex with Interleukin 15 receptor alpha'''
===Crystal structure of Interleukin 15 in complex with Interleukin 15 receptor alpha===




==Overview==
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Interleukin (IL)-15 is a pleiotropic cytokine that plays a pivotal role in both innate and adaptive immunity. IL-15 is unique among cytokines due to its participation in a trans signaling mechanism in which IL-15 receptor alpha (IL-15Ralpha) from one subset of cells presents IL-15 to neighboring IL-2Rbeta/gammac-expressing cells. Here we present the crystal structure of IL-15 in complex with the sushi domain of IL-15Ralpha. The structure reveals that the alpha receptor-binding epitope of IL-15 adopts a unique conformation, which, together with amino acid substitutions, permits specific interactions with IL-15Ralpha that account for the exceptionally high affinity of the IL-15.IL-15Ralpha complex. Interestingly, analysis of the topology of IL-15 and IL-15Ralpha at the IL-15.IL-15Ralpha interface suggests that IL-15 should be capable of participating in a cis signaling mechanism similar to that of the related cytokine IL-2. Indeed, we present biochemical data demonstrating that IL-15 is capable of efficiently signaling in cis through IL-15Ralpha and IL-2Rbeta/gammac expressed on the surface of a single cell. Based on our data we propose that cis presentation of IL-15 may be important in certain biological contexts and that flexibility of IL-15Ralpha permits IL-15 and its three receptor components to be assembled identically at the ligand-receptor interface whether IL-15 is presented in cis or trans. Finally, we have gained insights into IL-15.IL-15Ralpha.IL-2Rbeta.gammac quaternary complex assembly through the use of molecular modeling.
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{{ABSTRACT_PUBMED_17947230}}


==About this Structure==
==About this Structure==
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[[Category: Sushi]]
[[Category: Sushi]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:44:05 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:22:00 2008''

Revision as of 12:22, 28 July 2008

File:2psm.png


Drag the structure with the mouse to rotate
2psm, resolution 2.19Å (default scene)
Ligands: BAM
Gene: Il15 (Mus musculus), Il15ra (Mus musculus)
Resources: FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Interleukin 15 in complex with Interleukin 15 receptor alpha

Template:ABSTRACT PUBMED 17947230

About this Structure

2PSM is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation., Olsen SK, Ota N, Kishishita S, Kukimoto-Niino M, Murayama K, Uchiyama H, Toyama M, Terada T, Shirouzu M, Kanagawa O, Yokoyama S, J Biol Chem. 2007 Dec 21;282(51):37191-204. Epub 2007 Oct 18. PMID:17947230

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