2q11: Difference between revisions

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-[[Image:2q11.jpg|left|200px]]
+{{Seed}}
+[[Image:2q11.png|left|200px]]
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 {{STRUCTURE_2q11|  PDB=2q11  |  SCENE=  }}
-'''Structure of BACE complexed to compound 1'''
+===Structure of BACE complexed to compound 1===
-==Overview==
+<!--
-A new aspartic protease inhibitory chemotype bearing a 2-amino-3,4-dihydroquinazoline ring was identified by high-throughput screening for the inhibition of BACE-1. X-ray crystallography revealed that the exocyclic amino group participated in a hydrogen bonding array with the two catalytic aspartic acids of BACE-1 (Asp(32), Asp(228)). BACE-1 inhibitory potency was increased (0.9 microM to 11 nM K(i)) by substitution into the unoccupied S(1)' pocket.
+The line below this paragraph, {{ABSTRACT_PUBMED_17685503}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17685503 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17685503}}
 ==About this Structure==
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 [[Category: Bace inhibitor complex]]
 [[Category: Hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:08:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:10:46 2008''

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