2q5d: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:2q5d.jpg|left|200px]]
{{Seed}}
[[Image:2q5d.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2q5d|  PDB=2q5d  |  SCENE=  }}  
{{STRUCTURE_2q5d|  PDB=2q5d  |  SCENE=  }}  


'''Crystal Structure of Human Importin Beta bound to the Snurportin1 IBB-domain second crystal form'''
===Crystal Structure of Human Importin Beta bound to the Snurportin1 IBB-domain second crystal form===




==Overview==
<!--
The nuclear import of uridine-rich ribonucleoproteins (U snRNPs) is mediated by the transport adaptor snurportin 1 (SNP1). Similar to importin alpha, SNP1 uses an N-terminal importin beta binding (sIBB) domain to recruit the receptor importin beta and gain access to the nucleus. In this paper, we demonstrate the sIBB-domain has a bipartite nature, which contains two distinct binding determinants for importin beta. The first determinant spans residues 25-65, and includes the previously identified alphaIBB-region of homology. The second binding determinant encompasses residues 1-24 and resembles region 1011-1035 of the nucleoporin 153 (Nup153). The two binding determinants synergize within the sIBB-domain to confer a low nanomolar binding affinity for importin beta, (Kd ~2nM) in an interaction that, in vitro, is displaced by RanGppNHp. We propose that in vivo the synergy of Nup153 and nuclear RanGTP promotes translocation of U snRNPs into the nucleus.
The line below this paragraph, {{ABSTRACT_PUBMED_18187419}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18187419 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_18187419}}


==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Protein transport]]
[[Category: Protein transport]]
[[Category: Snurportin]]
[[Category: Snurportin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:23:09 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:47:03 2008''

Revision as of 13:47, 27 July 2008

File:2q5d.png

Template:STRUCTURE 2q5d

Crystal Structure of Human Importin Beta bound to the Snurportin1 IBB-domain second crystal form

Template:ABSTRACT PUBMED 18187419

About this Structure

2Q5D is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular basis for the recognition of snurportin 1 by importin beta., Mitrousis G, Olia AS, Walker-Kopp N, Cingolani G, J Biol Chem. 2008 Jan 9;. PMID:18187419

Page seeded by OCA on Sun Jul 27 16:47:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2q5d&oldid=656563"