2q5i: Difference between revisions

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[[Image:2q5i.~~jpg~~|left|200px]]

[[Image:2q5i.png|left|200px]]

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~~'''~~Crystal structure of apo S581L Glycyl-tRNA synthetase mutant~~'''~~

===Crystal structure of apo S581L Glycyl-tRNA synthetase mutant===

~~==Overview==~~

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~~Dominant mutations in the ubiquitous enzyme glycyl-tRNA synthetase (GlyRS)~~, ~~including S581L~~, ~~lead~~ to ~~motor nerve degeneration~~. ~~We have determined crystal structures of wildtype and S581L-mutant human GlyRS~~. ~~The S581L mutation~~ is ~~approximately 50A from the active site, and yet gives reduced aminoacylation activity. The overall structures of wildtype and S581L-GlyRS, including~~ the ~~active site, are very similar~~. ~~However, residues 567~~-~~575 of the anticodon~~-binding domain shift position and in turn could indirectly affect glycine binding via the tRNA or alternatively inhibit conformational changes. Reduced enzyme activity may underlie neuronal degeneration, although a dominant-negative effect is more likely in this autosomal dominant disorder.

The line below this paragraph, {{ABSTRACT_PUBMED_17544401}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17544401 is the PubMed ID number.

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==Disease==

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[[Category: Oxford protein production facility]]

[[Category: Structural genomic]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 14~~:23:41 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:09:07 2008''

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-[[Image:2q5i.jpg|left|200px]]
+{{Seed}}
+[[Image:2q5i.png|left|200px]]
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 {{STRUCTURE_2q5i|  PDB=2q5i  |  SCENE=  }}
-'''Crystal structure of apo S581L Glycyl-tRNA synthetase mutant'''
+===Crystal structure of apo S581L Glycyl-tRNA synthetase mutant===
-==Overview==
+<!--
-Dominant mutations in the ubiquitous enzyme glycyl-tRNA synthetase (GlyRS), including S581L, lead to motor nerve degeneration. We have determined crystal structures of wildtype and S581L-mutant human GlyRS. The S581L mutation is approximately 50A from the active site, and yet gives reduced aminoacylation activity. The overall structures of wildtype and S581L-GlyRS, including the active site, are very similar. However, residues 567-575 of the anticodon-binding domain shift position and in turn could indirectly affect glycine binding via the tRNA or alternatively inhibit conformational changes. Reduced enzyme activity may underlie neuronal degeneration, although a dominant-negative effect is more likely in this autosomal dominant disorder.
+The line below this paragraph, {{ABSTRACT_PUBMED_17544401}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17544401 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17544401}}
 ==Disease==
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 [[Category: Oxford protein production facility]]
 [[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:23:41 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:09:07 2008''