2q70: Difference between revisions

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[[Image:2q70.jpg|left|200px]]
{{Seed}}
[[Image:2q70.png|left|200px]]


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{{STRUCTURE_2q70|  PDB=2q70  |  SCENE=  }}  
{{STRUCTURE_2q70|  PDB=2q70  |  SCENE=  }}  


'''Estrogen receptor alpha ligand-binding domain complxed to a benzopyran ligand'''
===Estrogen receptor alpha ligand-binding domain complxed to a benzopyran ligand===




==Overview==
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Benzopyrans are selective estrogen receptor (ER) beta agonists (SERBAs), which bind the ER subtypes alpha and beta in opposite orientations. Here we describe the syntheses of cyclopentanone and cyclohexanone intermediates for SAR studies of the C-ring on the benzopyran scaffold. Modification of the C-ring disrupts binding to ERalpha, thus improving ERbeta selectivity up to 100-fold. X-ray cocrystal structures confirm previously observed binding modes.
The line below this paragraph, {{ABSTRACT_PUBMED_17614275}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17614275 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17614275}}


==About this Structure==
==About this Structure==
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[[Category: Estrogen receptor]]
[[Category: Estrogen receptor]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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