2q73: Difference between revisions

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[[Image:2q73.jpg|left|200px]]
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[[Image:2q73.png|left|200px]]


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{{STRUCTURE_2q73|  PDB=2q73  |  SCENE=  }}  
{{STRUCTURE_2q73|  PDB=2q73  |  SCENE=  }}  


'''Crystal structure of iMazG from Vibrio DAT 722: Ctag-iMazG (P41212)'''
===Crystal structure of iMazG from Vibrio DAT 722: Ctag-iMazG (P41212)===




==Overview==
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Mobile gene cassettes collectively contain a highly diverse pool of novel genes that encode many novel adaptive functions. In the non-clinical context, the function of almost all of the encoded proteins remains unknown despite the enormous size of this mobile gene pool. We have been characterizing cassette arrays by taking advantage of the fact that they cluster at discrete sites in chromosomes; even large arrays are thus recoverable in a relatively small number of clones in genomic libraries. In one assembled array of 116 cassettes from the marine bacterium Vibrio sp. DAT722, a putative MazG protein is encoded within the 21st cassette. Because MazG proteins are implicated in a number of cellular processes, including house-cleaning and stress survival, the presence of such a protein in a mobile cassette was noteworthy. Here we solve the crystal structure of this alpha-helical protein, and define both open and closed states of a new variant of the MazG family. Functional assays confirm that the protein is a dNTP pyrophosphohydrolase, with marked preferences for dCTP and dATP. We hypothesize that iMazG acts as a house-cleaning enzyme, preventing the incorporation of damaging non-canonical nucleotides into host-cell DNA.
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{{ABSTRACT_PUBMED_17892463}}


==About this Structure==
==About this Structure==
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[[Category: Ntp-ppase]]
[[Category: Ntp-ppase]]
[[Category: Vibrio]]
[[Category: Vibrio]]
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Revision as of 03:19, 29 July 2008

File:2q73.png

Template:STRUCTURE 2q73

Crystal structure of iMazG from Vibrio DAT 722: Ctag-iMazG (P41212)

Template:ABSTRACT PUBMED 17892463

About this Structure

2Q73 is a Single protein structure of sequence from Vibrio sp. dat722. Full crystallographic information is available from OCA.

Reference

A putative house-cleaning enzyme encoded within an integron array: 1.8 A crystal structure defines a new MazG subtype., Robinson A, Guilfoyle AP, Harrop SJ, Boucher Y, Stokes HW, Curmi PM, Mabbutt BC, Mol Microbiol. 2007 Nov;66(3):610-21. Epub 2007 Sep 24. PMID:17892463

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