2q7f: Difference between revisions

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[[Image:2q7f.jpg|left|200px]]
{{Seed}}
[[Image:2q7f.png|left|200px]]


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{{STRUCTURE_2q7f|  PDB=2q7f  |  SCENE=  }}  
{{STRUCTURE_2q7f|  PDB=2q7f  |  SCENE=  }}  


'''Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site'''
===Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site===




==Overview==
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YrrB is a hypothetical protein containing a tetratricopeptide repeat (TPR) domain from a Gram-positive bacterium, Bacillus subtilis. We determined YrrB structure in the C2 space group to 2.5A resolution, which is the first TPR structure of the Gram-positive bacterium B. subtilis. In contrast to other known TPR structures, the concave surface of the YrrB TPR domain is composed of the putative peptide-binding pocket lined with positively-charged residues. This unique charge distribution reveals that YrrB can interact with partner proteins via an unusual TPR-mediated interaction mode, compared to that of other TPR-containing structures. Functional annotation using genomics analysis suggested that YrrB may be an interacting mediator in the complex formation among RNA sulfuration components. No proteins containing a TPR domain have been identified in the biosynthesis of sulfur-containing biomolecules. Thus, YrrB could play a new role as a connecting module among those proteins in the conserved gene cluster for RNA sulfuration.
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{{ABSTRACT_PUBMED_17624311}}


==About this Structure==
==About this Structure==
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[[Category: Tpr]]
[[Category: Tpr]]
[[Category: Yrrb]]
[[Category: Yrrb]]
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Revision as of 15:16, 27 July 2008

File:2q7f.png

Template:STRUCTURE 2q7f

Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site

Template:ABSTRACT PUBMED 17624311

About this Structure

2Q7F is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site., Han D, Oh J, Kim K, Lim H, Kim Y, Biochem Biophys Res Commun. 2007 Sep 7;360(4):784-90. Epub 2007 Jul 5. PMID:17624311

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