2q8o: Difference between revisions

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[[Image:2q8o.jpg|left|200px]]
{{Seed}}
[[Image:2q8o.png|left|200px]]


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{{STRUCTURE_2q8o|  PDB=2q8o  |  SCENE=  }}  
{{STRUCTURE_2q8o|  PDB=2q8o  |  SCENE=  }}  


'''crystal structure of mouse GITR ligand dimer'''
===crystal structure of mouse GITR ligand dimer===




==Overview==
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Glucocorticoid-induced TNF receptor ligand (GITRL) is a member of the TNF super family (TNFSF). GITRL plays an important role in controlling regulatory T cells. The crystal structure of the mouse GITRL (mGITRL) was determined to 1.8-A resolution. Contrary to the current paradigm that all ligands in the TNFSF are trimeric, mGITRL associates as dimer through a unique C terminus tethering arm. Analytical ultracentrifuge studies revealed that in solution, the recombinant mGITRL exists as monomers at low concentrations and as dimers at high concentrations. Biochemical studies confirmed that the mGITRL dimer is biologically active. Removal of the three terminal residues in the C terminus resulted in enhanced receptor-mediated NF-kappaB activation than by the wild-type receptor complex. However, deletion of the tethering C-terminus arm led to reduced activity. Our studies suggest that the mGITRL may undergo a dynamic population shift among different oligomeric forms via C terminus-mediated conformational changes. We hypothesize that specific oligomeric forms of GITRL may be used as a means to differentially control GITR receptor signaling in diverse cells.
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{{ABSTRACT_PUBMED_18178614}}


==About this Structure==
==About this Structure==
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[[Category: Tnf]]
[[Category: Tnf]]
[[Category: Unknown function]]
[[Category: Unknown function]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:32:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:45:58 2008''

Revision as of 05:46, 29 July 2008

File:2q8o.png

Template:STRUCTURE 2q8o

crystal structure of mouse GITR ligand dimer

Template:ABSTRACT PUBMED 18178614

About this Structure

2Q8O is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for ligand-mediated mouse GITR activation., Zhou Z, Tone Y, Song X, Furuuchi K, Lear JD, Waldmann H, Tone M, Greene MI, Murali R, Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):641-5. Epub 2008 Jan 4. PMID:18178614

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