2q9b: Difference between revisions

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[[Image:2q9b.jpg|left|200px]]
{{Seed}}
[[Image:2q9b.png|left|200px]]


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{{STRUCTURE_2q9b|  PDB=2q9b  |  SCENE=  }}  
{{STRUCTURE_2q9b|  PDB=2q9b  |  SCENE=  }}  


'''Structure of FTSY:GMPPNP Complex'''
===Structure of FTSY:GMPPNP Complex===




==Overview==
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The signal recognition particle (SRP) and its conjugate receptor (SR) mediate cotranslational targeting of a subclass of proteins destined for secretion to the endoplasmic reticulum membrane in eukaryotes or to the plasma membrane in prokaryotes. Conserved active site residues in the GTPase domains of both SRP and SR mediate discrete conformational changes during formation and dissociation of the SRP.SR complex. Here, we describe structures of the prokaryotic SR, FtsY, as an apo protein and in two different complexes with a non-hydrolysable GTP analog (GMPPNP). These structures reveal intermediate conformations of FtsY containing GMPPNP and explain how the conserved active site residues position the nucleotide into a non-catalytic conformation. The basis for the lower specificity of binding of nucleotide in FtsY prior to heterodimerization with the SRP conjugate Ffh is also shown. We propose that these structural changes represent discrete conformational states assumed by FtsY during targeting complex formation and dissociation.
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{{ABSTRACT_PUBMED_17622352}}


==About this Structure==
==About this Structure==
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[[Category: Signal recognition particle]]
[[Category: Signal recognition particle]]
[[Category: Srp]]
[[Category: Srp]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:34:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:24:10 2008''

Revision as of 06:24, 28 July 2008

File:2q9b.png

Template:STRUCTURE 2q9b

Structure of FTSY:GMPPNP Complex

Template:ABSTRACT PUBMED 17622352

About this Structure

2Q9B is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates., Reyes CL, Rutenber E, Walter P, Stroud RM, PLoS ONE. 2007 Jul 11;2(7):e607. PMID:17622352

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