2qfb: Difference between revisions

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[[Image:2qfb.jpg|left|200px]]
{{Seed}}
[[Image:2qfb.png|left|200px]]


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{{STRUCTURE_2qfb|  PDB=2qfb  |  SCENE=  }}  
{{STRUCTURE_2qfb|  PDB=2qfb  |  SCENE=  }}  


'''Crystal structure of the regulatory domain of human RIG-I with bound Zn'''
===Crystal structure of the regulatory domain of human RIG-I with bound Zn===




==Overview==
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The ATPase RIG-I senses viral RNAs that contain 5'-triphosphates in the cytoplasm. It initiates a signaling cascade that activates innate immune response by interferon and cytokine production, providing essential antiviral protection for the host. The mode of RNA 5'-triphosphate sensing by RIG-I remains elusive. We show that the C-terminal regulatory domain RD of RIG-I binds viral RNA in a 5'-triphosphate-dependent manner and activates the RIG-I ATPase by RNA-dependent dimerization. The crystal structure of RD reveals a zinc-binding domain that is structurally related to GDP/GTP exchange factors of Rab-like GTPases. The zinc coordination site is essential for RIG-I signaling and is also conserved in MDA5 and LGP2, suggesting related RD domains in all three enzymes. Structure-guided mutagenesis identifies a positively charged groove as likely 5'-triphosphate-binding site of RIG-I. This groove is distinct in MDA5 and LGP2, raising the possibility that RD confers ligand specificity.
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{{ABSTRACT_PUBMED_18243112}}


==About this Structure==
==About this Structure==
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[[Category: Ubl conjugation]]
[[Category: Ubl conjugation]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:51:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:00:20 2008''

Revision as of 16:00, 27 July 2008

File:2qfb.png

Template:STRUCTURE 2qfb

Crystal structure of the regulatory domain of human RIG-I with bound Zn

Template:ABSTRACT PUBMED 18243112

About this Structure

2QFB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I., Cui S, Eisenacher K, Kirchhofer A, Brzozka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP, Mol Cell. 2008 Feb 1;29(2):169-179. PMID:18243112

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