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| {{STRUCTURE_2qfa| PDB=2qfa | SCENE= }} | | {{STRUCTURE_2qfa| PDB=2qfa | SCENE= }} |
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| '''Crystal structure of a Survivin-Borealin-INCENP core complex'''
| | ===Crystal structure of a Survivin-Borealin-INCENP core complex=== |
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| ==Overview==
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| The chromosomal passenger complex (CPC) is a key regulator of chromosome segregation and cytokinesis. CPC functions are connected to its localization. The complex first localizes to centromeres and later associates with the central spindle and midbody. Survivin, Borealin, and INCENP are the three components of the CPC that regulate the activity and localization of its enzymatic component, the kinase Aurora B. We determined the 1.4 A resolution crystal structure of the regulatory core of the CPC, revealing that Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle. We used siRNA rescue experiments with structure-based mutants to explore the requirements for CPC localization. We show that the intertwined structural interactions of the core components lead to functional interdependence. Association of the core "passenger" proteins creates a single structural unit, whose composite molecular surface presents conserved residues essential for central spindle and midbody localization. | | The line below this paragraph, {{ABSTRACT_PUBMED_17956729}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17956729 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17956729}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Three-helical-bundle]] | | [[Category: Three-helical-bundle]] |
| [[Category: Zinc]] | | [[Category: Zinc]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:51:27 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:58:40 2008'' |
